Case History

1. The high-grade pontine brainstem gliomas that occur in childhood are typical of _______ cell lineage.

A. neuronal
B. mixed glial-neuronal
C. ependymal
D. astrocytic
E. oligodendroglial

2. The characteristic genomic alteration in high-grade pontine brainstem gliomas is:

A. H3 K27M mutation
B. WNT activation
C. Non-retention of SMARCB1
D. RELA fusion
E. 1p and 19q codeletion


Answer #1: D. Astrocytic
Answer #2: A. H3 K27M mutation

Case contributed by: Kenneth Fallon, M.D., Associate Professor, Anatomic Pathology, Neuropathology