Case History

This is a 41 year old man with admitted from an outside hospital for encephalopathy.  Chest x-ray shows multiple nodules suggestive of disseminated tuberculosis.

What is the diagnosis?

  1.        Tuberculosis
  2.        Histoplasmosis
  3.        Coccidomycosis
  4.        Blastomycosis

  
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Case History

A 30-year-old man presented with a left elbow mass. A biopsy showed a small, blue, round cell tumor. The lesional cells were positive for myoD1, with very limited expression of desmin and myogenin.

What is the diagnosis?

  1.        Extraskeletal osteosarcoma
  2.        Ewing sarcoma
  3.        Embryonal rhabdomyosarcoma
  4.        Sclerosing rhabdomyosarcoma

  
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Case History

Images are from a 61-year-old male with 12 cm renal mass involving renal vein, sinus and perirenal fat.

Which statement is false regarding this case?

A. IHC for FH or 2-SC are recommended

B. This is a Type 2 Papillary RCC, no studies needed

C. TFEB-amplified RCC is in the ddx

D. MART1 expression by this tumor would not be a surprise

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Case History

A 59-year-old female with cystic liver lesion. Prior history of thyroid cancer 17 years ago. What is the diagnosis?

What is the diagnosis?

  1.        Metastatic follicular carcinoma
  2.        Hepatocellular carcinoma
  3.        Papillary mesothelioma 
  4.        Metastatic papillary thyroid carcinoma

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Case History

29-year old male with a 4.7 cm gastric mass. The immunoprofile of this tumor is CD117 -, DOG1 -, Sox10 + and CD68 +.

What is the diagnosis?

    1. Gastrointestinal Stromal Tumor (GIST)
    2. Leiomyoma
    3. Granular Cell Tumor (GCT)
    4. Malignant Gastrointestinal Neuroectodermal Tumor (MGINT) AKA “clear cell sarcoma-like tumor of the gastrointestinal tract”

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Case History

A 52-year-old male presents with an epistaxis and nasal obstruction. Imaging shows a 2.1 cm mass involving the cribriform plate of the ethmoid sinus. 

What is the diagnosis?

  1.       Neuroendocrine carcinoma
  2.       NUT carcinoma
  3.       Mucosal Melanoma
  4.       Olfactory Neuroblastoma

thumbnail_Branton_HE_100x_2.jpg thumbnail_Branton_HE_200x_3.jpgthumbnail_Branton_HE_100x.jpg cyto 5

Case History

A 21-year-old female with a history of seizures presents with heterogenous, cystic lesion measuring 4.0 x 4.0 x 3.8cm located in cortical temporal lobe, pictured below. What is the diagnosis and genetic mutation associated with it? 

Based on the pictures below, what is the most likely diagnosis.

  1.       Pilocytic Astrocytoma, WHO G1, BRAF
  2.       SEGA, WHO G1, TSC
  3.       Anaplastic PXA, WHO G3, BRAF
  4.       Intracranial Fibrous Histiocytoma, EWS

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Case History

A 62 year old female presents with leukocytosis (WBC 230k), fatigue, fevers and abdominal pain x1 month. CMP and LFTs are within normal limits. The neoplastic cells are negative for CD34 and TdT. 

Based on the pictures below, what is the most likely diagnosis.

  1.       Sezaly syndrome
  2.       Adult T-cell lymphoma/leukemia
  3.       T-cell leukemia with mature phenotype
  4.       T-Acute Lymphoblastic Leukemia/Lymphoma

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Case History

A 36-year-old male had a nonresectable pancreatic mass. There were bilateral lung lesions suspicious for metastasis. No renal lesion was identified.

What is the diagnosis?

  1.       Melanoma
  2.       Clear cell renal cell carcinoma
  3.       Carcinoma
  4.       Pecoma

Picture1  Case of the week 2 
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