Case History

A 17-year-old young lady presenting with a pancreatic neck mass.

What is the most appropriate diagnosis?

  1. Nondiagnostic specimen
  2. Negative for malignant cells
  3. Atypical cells present
  4. Neoplastic cells present 

Figure 1 Figure 2   
Figure 3 Figure 4

Case History

A 34-year-old man with pancytopenia, mediastinal mass and splenomegaly. Bone marrow flow cytometry showed an abnormal population with this phenotype: CD45lo, cytoplasmic CD3-, CD19-, CD10-, CD34+, CD13heterogeneous, CD33 heterogeneous, HLA-DR+, TdT+, MPO-. What is the diagnosis?

  1. Acute myeloid leukemia
  2. T-Acute lymphoblastic leukemia
  3. Acute undifferentiated leukemia
  4. Mixed phenotype acute leukemia

 Question Photo 1 Bone marrow flow cytometry Question Photo 2 Bone marrow biopsy   

Case History

A 59-year-old male presents with heavy proteinuria, hypoalbuminemia and normal kidney function. No other significant medical history. The findings of the kidney biopsy are classic for this entity. What antibody is associated with this diagnosis?

  1. PLA2R
  2. ANA
  3. ANCA
  4. Anti-GBM

 Question Photo 1 Question Photo 2 Question Photo 3  Question Photo 4

Case History

A 35-year-old male presents with scrotal pain and a 1-cm testis mass is identified on ultrasound. A frozen section is performed. What is the diagnosis?

  1.       Leydig Cell Tumor
  2.       Seminoma
  3.       Embryonal Carcinoma
  4.       Spermatocytic Tumor

 Question Photo 1  Question Photo 2 Question Photo 3 

Case History

A 71-year-old female presents to an ENT for a soft palate mass. A biopsy is performed.

This neoplasm most often arises in the:

  1.        Parotid gland
  2.        Submandibular gland
  3.        Sublingual gland
  4.        Minor salivary glands

 Question Stem Photo 1 Question Stem Photo 2 Question Stem Photo 3 Question Stem Photo 4

Case History

61-year-old female with vaginal wall mass.

Answer choices:

  1. Fibroepithelial polyp
  2. Superficial myofibroblastoma
  3. Keloid
  4. Cellular angiofibroma

 Picture1 Picture2 Picture3 

Case History

A 39-year-old female with abnormal vaginal bleeding, history of abnormal Pap smears, and LEEP for HSIL. The patient had a full term delivery two years ago. Hysterectomy was performed.  Section of the lower uterine segment is illustrated.

  1. Intermediate trophoblastic tumor (epithelioid trophoblastic tumor)
  2. Squamous cell carcinoma
  3. Placental site nodule
  4. Exaggerated placental site

 Question FIG 1 Question FIG 2
 Question FIG 3 Question FIG 4

Case History

A 61-year-old man with a 6-month history of right parotid mass and lymphadenopathy.

  1.       High-grade salivary duct carcinoma
  2.       Oncocytic mucoepidermoid carcinoma
  3.       Poorly differentiated squamous carcinoma
  4.       Mammary analogue secretory carcinoma

 Hi grade composite

Case History

A 60-year-old woman presented with a small, irregular breast mass on imaging. A biopsy was performed.

  1.        Invasive ductal carcinoma, grade 1
  2.        Invasive tubular carcinoma, grade 1
  3.        Radial scar
  4.        Sclerosing adenosis 

 Case of the Week Question Photo

Case History

A 75-year-old woman with suspected pancreatic NET undergoes a Whipple. The morphology of the tumor is seen in Fig A-D.  A synaptophysin is performed (Fig E).  What additional IHC profile can be expected in this tumor?

  1.        Nuclear beta-catenin (+), CK (-)
  2.        Chromogranin (+), Ki67 (>2% per HPF)
  3.        Trypsin (+), BCL10 (+)
  4.        Trypsin (+), Nuclear beta-catenin (+ in squamoid nests)

twitter question stem figure A twitter question stem figure B
twitter question stem figure C twitter question stem figure D