Case History

A 39-year-old female with abnormal vaginal bleeding, history of abnormal Pap smears, and LEEP for HSIL. The patient had a full term delivery two years ago. Hysterectomy was performed.  Section of the lower uterine segment is illustrated.

  1. Intermediate trophoblastic tumor (epithelioid trophoblastic tumor)
  2. Squamous cell carcinoma
  3. Placental site nodule
  4. Exaggerated placental site

 Question FIG 1 Question FIG 2
 Question FIG 3 Question FIG 4

Case History

A 61-year-old man with a 6-month history of right parotid mass and lymphadenopathy.

  1.       High-grade salivary duct carcinoma
  2.       Oncocytic mucoepidermoid carcinoma
  3.       Poorly differentiated squamous carcinoma
  4.       Mammary analogue secretory carcinoma

 Hi grade composite

Case History

A 60-year-old woman presented with a small, irregular breast mass on imaging. A biopsy was performed.

  1.        Invasive ductal carcinoma, grade 1
  2.        Invasive tubular carcinoma, grade 1
  3.        Radial scar
  4.        Sclerosing adenosis 

 Case of the Week Question Photo

Case History

A 75-year-old woman with suspected pancreatic NET undergoes a Whipple. The morphology of the tumor is seen in Fig A-D.  A synaptophysin is performed (Fig E).  What additional IHC profile can be expected in this tumor?

  1.        Nuclear beta-catenin (+), CK (-)
  2.        Chromogranin (+), Ki67 (>2% per HPF)
  3.        Trypsin (+), BCL10 (+)
  4.        Trypsin (+), Nuclear beta-catenin (+ in squamoid nests)

twitter question stem figure A twitter question stem figure B
twitter question stem figure C twitter question stem figure D

Case History

53-year-old female with uterine mass.

What is the diagnosis?

A. Endometrial stromal sarcoma, low grade
B. Epithelioid leiomyoma
C. Adenosarcoma
D. PEComa

Photo for Question

Case History

A 73-year-old female with a left parotid mass. Fine needle aspirate. What is the best cytomorphologic diagnosis?

  1.       Pleomorphic adenoma
  2.       Adenoid cystic carcinoma
  3.       High-grade mucoepidermoid carcinoma 
  4.       Mammary analogue secretory carcinoma

Picture1Picture2Picture3 Picture4

Case History

The patient is a 29 year-old female with clinical history of shortness of breath and fevers. Routine imaging studies showed multiple pleural nodules. CBC and routine chemistries are within normal limits with mild increase of LDH. Open biopsy of the nodules obtained.

What is the diagnosis?

  1. Mesothelioma
  2. Germ cell tumor
  3. Anaplastic large cell lymphoma
  4. Thymoma

Thy 02 Thy 03 Thy 04 Thy 04

Case History

56-year-old female with left floor of mouth erythematous lesion

What is the diagnosis:

  1.        Melanoma
  2.        Myoepithelioma
  3.        Epithelioid Schwannoma
  4.        Ectomesenchymal Chondromyxoid Tumor (ECMT)

1 2

Case History

66-year-old male with mild splenomegaly. HB: 17.5 g/dL; HCT: 52%; WBC: 10.1 10^3/cm; PLT: 948 10^3/cm. Blasts <1% in bone marrow. JAK2+

1 question 2 question

What is the diagnosis:

  1.         PMF, prefibrotic stage
  2.         PMF, fibrotic stage
  3.         ET
  4.         PV

Case History

A 62 year-old man presenting with jaundice, pancreatic duct/common bile duct dilation and ampullary mass.

 What is the most appropriate diagnosis?

    1.        Nondiagnostic specimen
    2.        Negative for malignant cells
    3.        Atypical cells present
    4.        Neoplastic cells present
    5.        Adenocarcinoma

Figure 1 Figure 2 Figure 3 Figure 4