Case of the Week
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Case History
A 48-year-old man presents with an incidental 3 cm right adrenal mass, undergoes right adrenalectomy. The tubular and canalicular structures are positive for calretinin.
- Adrenal cortical adenoma
- Metastatic signet ring cell carcinoma
- Adenomatoid tumor
- Composite adrenal cortical adenoma and adenomatoid tumor
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Case History
A 7 y/o M with pancytopenia and splenomegaly. Which one of the following is NOT included in DDx:
- Gaucher disease.
- MAC infection.
- Mast cell disorder
- Whipple disease
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Case History
The patient is a 35-year-old-female with leukocytosis. Peripheral blood findings showed increased blasts consistent with acute leukemia. The morphology is suggestive of which genetic abnormality?
A. RUNX1-RUNX1T1
B. MLLT3-MLL
C. PML-RARA
D. CBFB-MYH11
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Case History
A 48-year-old woman underwent a hysterectomy for a uterine mass. The neoplastic cells stained positive for CD10, ER, SMA, focal cyclin D1, and negative for desmin, caldesmon, STST6, SF1, and HMB-45. Sarcoma fusion panel showed JAZF1-SUZ12 fusion.
What is the correct diagnosis?
B. Endometrial stromal nodule
C. Low-grade endometrial stromal sarcoma
D. Smooth muscle tumor of uncertain malignant potential (STUMP)
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Case History
22-year-old female with hilar and mediastinal lymphadenopathy, FNA of mediastinal lymph node.
What stains would you order to further work up the case?
B. CD15, CD30
C. CK7, CK20
D. Gata-3, Mammaglobin
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Case History
This is a fine needle aspiration of a 4.1 cm indeterminate soft tissue mass in the pancreatic head of a 41-year-old male.
What is the most likely diagnosis?
B. Neurofibroma
C. GIST
D. Fibromyxoid sarcoma
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Case History
30-year-old presenting with bilateral papilledema and vision problems. Neuroimaging reveals a 2.7 x 2.1 cm right cerebellar mass
What is the most likely diagnosis?
B. Melanoma
C. Hemangioblastoma
D. Angiosarcoma
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Case History
39-year-old female, endometrial biopsy
What is the most likely diagnosis?
B. Endometrial stromal nodule with sex cord-like differentiation
C. Highly cellular leiomyoma
D. Endometrial polyp
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Case History
A 16-year old female presents with abnormal uterine bleeding. A 3.5 cm submucosal leiomyoma is clinically suspected, and she underwent a hysteroscopic myomectomy.
What is the most likely diagnosis?
B. Atypical polyploid adenoma
C. Benign adenomyomatous polyp
D. Benign endometrial polyp
